1st Edition
Gene Therapy for Neurological Disorders Molecular Approaches for Targeted Treatment
Neurological illnesses pose one of the biggest hazards to the healthcare system today. The range of pharmacotherapeutics currently available have a range of palliative effects and are ineffective in treating such neurological illnesses. This new book, Gene Therapy for Neurological Disorders: Molecular Approaches for Targeted Treatment, brings together the latest methods of gene therapy that can be used to treat both inherited and sporadic neurodegenerative diseases.
The book presents the most significant advances in gene transfer methods as well as the most recent understandings of the mechanisms behind specific neurodegenerative illnesses, placing these into the context of gene therapy approaches for the central nervous system. The book introduces the basics of neurodegenerative conditions and its physiological basis for their occurrence in humans. It also discusses the various proteins useful in neuro diseases and their viral applications. The book explores how stem cells can be used to learn about the future of gene therapy along with the significance of the sequences that silence genes. It discusses the functionS of astrocytes in the various brain regions, as well as in-vivo research in gene therapy for neurodegenerative disorders.
With the latest information on gene therapy in treating neurological disorders, this book is a comprehensive resource on the topic of gene therapy for neurological conditions. This volume will help pharmacologists, clinical researchers, and others to find a solution to treating neurological illnesses.
1. Neurodegenerative Disorders and Their Treatment
2. Neurodegenerative Disorder: A Mysterious Group of Diseases
3. Neurodegenerative Diseases Spread Like Prion Viruses
4. Gene Therapy: A Promising Strategy for the Treatment of Brain Disease
5. Stem-Cell-Employed Gene Therapy for Neurodegenerative Disorders
6. Current Practice and Prospects in Gene Therapy Based on Genomic DNA
7. Targeting Oligodendrocytes with Gene-Silencing Sequences through Vector-Mediated Transgene Delivery
8. Astrocytes: Genetic Treatment Targets for Alzheimer‘s Disease
9. Clinical Studies of Gene Therapy for the Treatment of Neurodegenerative Disorders
Biography
Rishabha Malviya, PhD, has 11 years of research experience and is presently working as Associate Professor in the Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India. His areas of interest include formulation optimization, nanoformulation, targeted drug delivery, localized drug delivery, and characterization of natural polymers as pharmaceutical excipients. He has authored more than 150 research and review papers for national and international journals of repute. He holds over 50 patents and has published many papers in reputed national and international journals, for which he received an outstanding reviewer award from Elsevier. He has edited 13 books (Wiley, Springer Nature, CRC Press/Taylor and Francis, Apple Academic Press, River Publisher, Lambert, and OMICS Publishing Group) and authored 15 book chapters. His name has been included in the World’s Top 2% Scientists list by Elsevier BV and Stanford University. He is reviewer, editor, and editorial board member of more than 50 national and international journals. He was an invited author for the magazine Atlas of Science as well as a pharma magazine dealing with B2B industry, Ingredient South Asia. He completed a BPharm from Uttar Pradesh Technical University and MPharm (Pharmaceutics) from Gautam Buddha Technical University, Lucknow, Uttar Pradesh, India. His PhD (Pharmacy) work was in novel formulation development techniques.
Arun Kumar Singh, MPharm, is affiliated with the Department of Pharmacy, School of Medical & Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India. His areas of interest include nanoformulation, blockchain, IoT, machine learning, cancer, artificial intelligence, and big data. He has published three chapters in the field of big data. He has also published two review papers among which one is in Biochimica et Biophysica Acta (BBA): Reviews on Cancer.His strength is his research skill, innovative thinking, leadership qualities, decision-making ability, and positive thinking.
Priyanshi Goyal, MPharm, is affiliated with the Department of Pharmacy at the School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh India. She completed her 10th and 12th years at Krishna International School (CBSE-affiliate), Aligarh, India. She also obtained her BPharm from Aligarh College of Pharmacy, Aligarh, affiliated with AKTU, Lucknow, and her MPharm from Galgotias University, Greater Noida, India.
Sonali Sundram, MPharm, is an Assistant Professor in the School of Medical and Allied Sciences at Galgotias University, Greater Noida, Uttar Pradesh, India. Previously, she worked as a research scientist on a project of ICMR at King George‘s Medical University, Lucknow, India. After that, she joined BBDNIIT (Babu Banarasi Das Northern India Institute of Technology), Lucknow. Her PhD (Pharmacy) work was in neurodegeneration and nanoformulation. Her areas of interest include neurodegeneration, clinical research, and artificial intelligence. She has edited four books (Wiley, CRC Press/Taylor and Francis, River Publisher) and has organized more than 15 national and international seminars, conferences, and workshops. She has more than eight patents, both national and international, to her credit. She completed both BPharm and MPharm (Pharmacology) degrees from Dr. A.P.J. Abdul Kalam Technical University, Lucknow, India.
