1st Edition
Handbook of Lipid Membranes Molecular, Functional, and Materials Aspects
This handbook provides a unique overview of lipid membrane fundamentals and applications. The fascinating world of lipids that harbor and govern so many biological functionalities are discussed within the context of membrane structures, interactions, and shape evolution. Beyond the fundamentals in lipid science, this handbook focuses on how scientists are building bioinspired biomimetic systems for applications in medicine, cosmetics, and nanotechnology.
Key Features:
- Includes experimental and theoretical overviews on the role of lipids, with or without associated biomolecules, as structural components imparting distinct membrane shapes and intermembrane interactions
- Covers the mechanisms of lipid-membrane curvature, by peptide and protein binding, and the roles of signalling lipids and the cytoskeleton in plasma membrane shape evolution
- Covers advanced X-ray and force measurement techniques
- Discusses applications in biomedicine, cosmetics, and nanotechnology, including lipid vectors in nucleic acid, drug delivery in dermal applications, and lipid-based sensors and artificial biointerfaces
- Covers artificial membranes from block copolymers, synthetic copolypeptides, and recombinant proteins
- Includes an exciting section that explores the role of lipids in the origin of life in hydrothermal conditions
This book is a highly informative companion for professionals in biophysics, biochemistry, physical chemistry, and material and pharmaceutical sciences and bioengineering.
Preface
Editors
Contributors
Chapter 1 A Short History of Membrane Physics
Erich Sackmann and Avinoam Ben-Shaul
Chapter 2 Structures and Interactions in Freely Suspended Multilayer Membranes and Dilute Lamellar Fluid Membranes from Synchrotron X-Ray Scattering
Gregory S. Smith and Cyrus R. Safinya
Chapter 3 Structures of Lipid Membranes: Cubic and Inverse Hexagonal Phases
Charlotte E. Conn and John M. Seddon
Chapter 4 Structure of Lipid Membranes by Advanced X-Ray Scattering and Imaging
Tim Salditt
Chapter 5 Adhesion Protein Architecture and Intermembrane Potentials: Force Measurements and Biological Significance
Deborah E. Leckband
Chapter 6 Charged Membranes: Poisson・Boltzmann Theory, the DLVO Paradigm, and Beyond
Tomer Markovich, David Andelman, and Rudolf Podgornik
Chapter 7 Membrane Shape Evolution In Vitro
Alexandra Zidovska
Chapter 8 Mechanisms of Membrane Curvature Generation by Peptides and Proteins: A Unified Perspective on Antimicrobial Peptides
Michelle W. Lee, Nathan W. Schmidt, and Gerard C. L. Wong
Chapter 9 Lipid Membrane Shape Evolution and the Actin Cytoskeleton
David R. Slochower, Yu-Hsiu Wang, Ravi Radhakrishnan, and Paul A. Janmey
Chapter 10 Effects of Osmotic Stress on Topologically Closed Membrane Compartments
James C. S. Ho, Bo Liedberg, and Atul N. Parikh
Chapter 11 Cationic Liposomes as Spatial Organizers of Nucleic Acids in One, Two, and Three Dimensions: Liquid Crystal Phases with Applications in Delivery and Bionanotechnology
Cyrus R. Safinya, Kai K. Ewert, Youli Li, and Joachim O. Rädler
Chapter 12 Lipids in DNA, RNA, and Peptide Delivery for In Vivo Therapeutic Applications
Tyler Goodwin and Leaf Huang
Chapter 13 Electrostatics of Lipid Membranes Interacting with Oppositely Charged Macromolecules
Guilherme Volpe Bossa, Klemen Bohinc, and Sylvio May
Chapter 14 Lipid-Based Bioanalytical Sensors
Marta Bally, Hudson Pace, and Fredrik Hook
Chapter 15 Lipids in Dermal Applications: Cosmetics and Pharmaceutics
Jerome Bibette and Abdou Rachid Thiam
Chapter 16 Supported Lipid Bilayers
Theo Lohmuller, Bert Nickel, and Joachim O. Rädler
Chapter 17 Artificial Membranes Composed of Synthetic Copolypeptides
Timothy J. Deming
Chapter 18 Synthetic Membranes from Block Copolymers, Recombinant Proteins, and Dendrimers
Daniel A. Hammer, Zhichun Wang, Ellen Reed, Chen Gao, and Kevin B. Vargo
Chapter 19 Amphiphilic Self-Assembly and the Origin of Life in Hydrothermal Conditions
Christos D. Georgiou and David W. Deamer
Index
Biography
Cyrus R. Safinya is professor of physics at the University of California, Santa Barbara, USA.
Joachim O. Rädler is professor of experimental physics at Ludwig-Maximilians-Universität München, Germany.