1st Edition
Handbook of Proteases in Cancer Cellular and Molecular Aspects
This handbook provides comprehensive coverage of the role of proteases and the associated biochemical pathways in cancer development and metastasis. Proteases make up to two percent of the human genome and play a critical role in the tumor microenvironment. The book introduces the major classes of proteases and the signal transduction mechanisms associated with cancer initiation and progression. It discusses the role of inflammation and immune responses in proteases-induced cancer. The book covers cancer-induced gene expression and apoptotic and necrotic pathways in cancer. The text is useful for researchers and professionals in cancer research, biochemistry, and physiology.
I. General Aspects
1.1. Calpain as a therapeutic target in B-cell lymphoma and other malignant diseases
Azizul Haque1,2,3* Naren L. Banik1,2,3
. 1.2 Proteases in cancer: Theoretical insights on the proteases’ evolutionary pathway
Salvatore Chirumbolo1,2*, Geir Bjorklund, Luigi Valdenassi, Sergio Pandolfi2, Umberto Tirelli4, Antonio Vella
. 1. 3 Role of extracellular proteases in Glioblastoma
Ira Sharma, Febe Ferro, Lynden Guy Nicely, Sourav Banerjee
. 1. 4 Metalloprotease in colon cancer proliferation and metastasis
Mubarak Labaran Liman1, Paul T. Olonishuwa2, Uju Dorathy Iliemene
. 1.5 Role of proteolytic enzymes in colon cancer
Keerthi #, Ameena Farhana1#, Diptimayee Das1, Antara Banerjee1, Surajit Pathak
1.6. Tumor associated fibroblast and ADAMS orchestrate tumor microenvironment in hepatocellular carcinoma
Shivani Sethuraman, Mohanprasanth Aruchamy, Sudhandiran Ganapasam
1.7 Unmasking the Protease Paradigm: Exploring the Molecular
Complexity of Proteases in Breast Cancer
Mohd Mustafa1, Kashif Abbas2, Mudassir Alam2, Sidra Islam3, Irfan Qadir Tantry4, Neda Tufail1, Rizwan Ahmad1, Bazigha Hamim1, Waleem Ahmad5, Hamda Khan1, Moinuddin1, Imtaiyaz Hassan6, Nazura Usmani2, Safia Habib
1. 8 Roles of MM7 in cancer
Angshuman Bagchi
1.9. The Role of Matrix Metalloproteinases MMP2 and MMP9 in Ovarian Cancer Progression
Shreya Bandopadhyay, Udit Dey, Subhadip Kundu, Debabrata Laik , Parna Chakraborty, Pallabi Debnath, Sib Sankar Roy
II. Signal Transduction Mechanisms
2.1. Role of calpains in cancer: an overview
Sajal Chakraborti*, Mahasweta Ghosh, Kausik Mondal, Priyanka Ghosh, Tapati Chakraborti
2.2. Dual role of the ADAMTS family in breast cancer
Álvaro J Obaya , Tania Fontanil
2.3. PKC isoforms and autophagy in cancer
Alakananda Basu*, Hope K. Fiadjoe
2.4. Mechanistic insights into the ferroptotic regulation of ubiquitin specific proteases in gastrointestinal tumors
Showket Yahya, Rabitha Ravichandiran, Sudhandiran Ganapasam
2.5. Serine proteases as critical modulators of the tumor microenvironment
Dipita Bhakta-Guha*, Gunjan Guha
2.6. Protease paradigm in cancer progression: Roles of Caspase-8 and matrix metalloproteinase family in cancer with special reference to head and neck squamous cell carcinoma
Shouvik Chakravarty¹,2, Arnab Ghosh¹,2, Pratyusha Chikkala¹,2, Nidhan K Biswas
2.7. ENTPDs in the tumor microenvironment: A promising context for cancer diagnosis
Soni Shaikh
2.8 Matrix Metalloproteases in Breast Cancer
Dimple Patel, Sanu Thankachan1, KP Kavitha, Saraswathy Sreeram, Shama Prasada Kabbekodu4, Padmanaban S Suresh
2.9. Targeting EGFR-driven signaling of MMP-2 secretion for the management of metastatic cancers
.: Loganayaki Periyasamy1, Abhaya Krishnan2, Sneha Krishnamoorthy1, Vishwanathan M3, Sridhar Muthusami1,4*
2.10 Protease in Signal Transduction Mechanism in Cancer: Unraveling the Role of Proteolytic Enzymes in Tumor Progression
Anjali Kumaria, Rajakishore Mishra
2.11. Sirtuin inhibition modifies matrix metalloproteinases in cancer
S.Sundaresan, S.K.Lavanya
2.12. Breast cancer metastasis– insight into Nexin-1 mediated signaling mechanism
Basavaraj Gorjanal, Monika B M, Monisha K M1, Gobianand Kuppannan2, Kanthesh M Basalingappa
2.13 The role of matrix metalloproteinase in molecular and cellular aspects of oral squamous cell carcinoma
Iyshwarya B K1, Ramakrishnan Veerabathiran1*, Ganesan Sivamani2, M.Nithyakalyani
2.14 The dichotomous role of CHIP in cancer
Mrinal K Ghosh1, Sunny Kumar1, Sayani Ghosh1, Malini Basu
III. Gene expression, apoptosis and necrosis
3.1 Mechanisms of apoptotic/necrotic cell death-related proteases: Cysteine and serine proteases
.: Eray Metin Guler1,2* and Beyza Nur Ozkan1
3.2. Apoptotic and non-apoptotic roles of caspases
Bharat Bhushan1*, Satish Kumar2, Ajay Pal3, Ajay Kumar4, Dharam Paul Choudhary1
3.3. Role of cysteine proteases and matrix metalloproteases in apoptosis and necrosis in cancer
Manal N. Abdel Azeem, Nour Y. S. Yassin, Noha A. Ahmed, Osama M. Ahmed
3.4. Role of SIRT1 in the regulation of gene expressions in breast cancer
Bidyadhar Das, Kitboklang Khongsti, Superior Syngkli and Riva Mary Rani
3.5. Future Vision of Protease Inhibitors in Context of Cocktail and Singular Therapy
Arunima Maiti1, Arunima Sinha2, Supratik Chatterjee2, Danial Kordbacheh3, Riddhi Goswami2, Sourav Banerjee4, Nilabja Sikdar2*
3.6. Regulation of cell death by cysteine proteases in breast cancer
Priyanka Saha, Anurima Samanta, Sukanya Ghosh, Rupa Chaudhuri, Dona Sinha
3.7. Ubiquitin Specific Protease 7 (USP7) – Role in human pathologies and potential targeting opportunities in cancer
.: Mrinal K Ghosh1, # ,*, Srija Roy1, #, Mouli Chatterjee1, Sabana Begam1 and Malini Basu
Biography
Dr. Sajal Chakraborti is a Professor at the Department of Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India. He did postdoctoral research at the Johns Hopkins Medical Institution, New York Medical College, the University of Utah, and the University of Florida. He has over 35 years of teaching and independent research experience in Biochemistry and Cell Biology. He has published over 110 original research papers, 15 review articles, and 12 books.