1st Edition
Synbiotics in Metabolic Disorders Mechanisms, Therapeutic Potential, and Future Perspectives
This book explores the potential role of prebiotics, probiotics, and synbiotics in managing various metabolic disorders, chronic diseases, and metabolic syndromes. The initial chapter provides an overview of metabolic disorders, including their classification, symptoms, and underlying causes. Additionally, the chapter discusses the intricate signaling pathways and mechanisms through which prebiotics, probiotics, and synbiotics interact with the human body in relation to type-2 diabetes, obesity, Phenylketonuria, and Hemochromatosis. Additionally, the book highlights the potential impact of probiotics and synbiotics on oxidative stress, inflammation, lipid metabolism, and blood pressure. Furthermore, this book focuses on the gut-brain axis and how synbiotics may influence neurotransmitter metabolism. With an emphasis on the gut-microbiota axis, this book presents a compelling narrative that explores the rationality behind synbiotic use and offers a glimpse into future perspectives for managing metabolic disorders effectively. This book is intended for researchers in the fields of nutraceuticals, nanomedicine, endocrinology, nutrition, gastroenterology, and metabolic medicine who are working in the field of probiotics, prebiotics, and symbiotics for the treatment of metabolic disorders.
Chapter 1: AN INTRODUCTION ON METABOLIC DISORDERS
Yash Jasoria1, Mohit Agrawal2, Hema Chaudhary3
Chapter 2: Targeting signaling pathway and mechanism of prebiotics, probiotics and symbiotics to manage metabolic disorders
Monika Kaushik1, Prathap Madeswaraguptha1, Murugesan Vanangamudi1, Vijayaraj Surendran2, Navaneetha Krishnan Subramaniyan2, Ashok Kumar3,*
Chapter 3: Potential Role of Probiotics, Prebiotics and Synbiotics in Management of Metabolic Syndrome and Chronic Metabolic Disease
Md. Khokon Miah Akanda, Sanzia Mehjabin
CHAPTER 4: SYNBIOTICS AND GUT MICRO FLORA: MECHANISMS AND THERAPEUTIC RATIONALITY AND CLINICAL APPLICATIONS FOR MANAGEMENT OF TYPE-2 DIABETES
Nisha Sharma1, Prakash Chandra Gupta1, Swarnakshi Upadhyay1, Kamla Pathak2*
Chapter 5: Therapeutic Potential of Gut Microbiota in Metabolic Disorders
Akash Kumar1, Jhilam Pramanik 2, Nandani Goyal3, Mukesh Kumar4, Aarzoo Jangra1, Bhagavathi Sundaram Sivamaruthi 5, 6, Bhupender Prajapati 7, Sudarshan Singh 5,8*, Popat Mohite 9, Abhijeet Puri9
Chapter 6: Therapeutic Potential of Gut Microbiota in Metabolic Disorders
Anas Islam, Aditya Singh, Asad Ahmad, Badruddeen1, Juber Akhtar1, Usama Ahmad1, Mohammad Irfan Khan1, Mohammad Ahmad, Yusuf Asad2*
Chapter 7: The Impact of probiotic and synbiotic supplementation on oxidative stress and inflammation
Himanshu Sharma1, Sanjesh Kumar2, Sumel Ashique3*, Pratibha Bhowmick3, Radheshyam Pal4, Arshad Farid5, Roomah Javed5, Farzad Taghizadeh-Hesary 6,7 , Subhajit Mandal8
Chapter 8: Correlation and Successive Role of Synbiotics to Manage Blood Pressure
Himanshu Sharma1*, Monika Kaushik2, Venishaa S3, Rashmi Pathak4, Arshad Farid5, Mithun Bhowmick6
Chapter 9: Synbiotics: A novel paradigm for Phenylketonuria management by targeting gut-microbiota and get-brain axis
Sana Fatima1, Muhammad Muzammal1, Shaista Naz1, Muzammil Ahmad Khan1, Alamgir Khan1, Arshad Farid1, Wasim shah2*
Chapter 10: Synbiotic: Potential Role in Hemochromoatosis Management
Monika Kaushik1*, Himanshu Sharma2, Prathap Madeswaraguptha1, Venishaa S3, Murugesan Vanangamudi1
Chapter 11: Correlation between synbiotic supplements and lipid metabolism: a novel strategy to counter attack metabolic disorders
Alamgir Khan1, Arshad Farid1, Fazal Haq2, Sohail Ahmad1, Amin Ullah3, Muhammad Muzammal1, Muhammad Ajmal Khan4*
Chapter 12: PROBIOTICS, PREBIOTICS, AND POSTBIOTICS ON METABOLIC DISEASES TARGETING GUT MICROBIOTA
Priyanka Ray1, Mohammad Abdul Faseeh2, Debojyoti Adak2*, Himanshu Sharma3
Chapter 13: Impact of Bacterial metabolites on the gut environment to manage metabolic disorders
Sohail Ahmad1, Maria Faraz1, Muhammad Badar1, Alamgir Khan1, Roomah Javed1, Arshad Farid 1*
Chapter 14: The Potential Role of Prebiotics, Probiotics, and Synbiotics in Cancer Prevention and Therapy
Phool Chandra1*, Himanshu Sharma1, Neetu Sachan2
Chapter 15: Key regulatory aspects of prebiotics, probiotics, and synbiotics in the management of metabolic disorders
Chapter 16: Synbiotics: Present Status and Future Prospectives to Control Metabolic Disorders
Sanzia Mehjabin1, Md. Khokon Miah Akanda2*, A. H. M. Nazmul Hasan2, G. M. Masud Parvez
Biography
Dr. Neeraj Mishra has been working as a Professor at Amity Institute of Pharmacy, Gwalior, since July 2019. He has around 20 years of teaching and research experience. He has more than 100 publications of international and national repute on recent concepts of novel drug delivery systems, oral delivery of synbiotics, localized drug delivery, and targeted and controlled drug delivery of nanocarriers and microparticles for the treatment of breast, colon, and neurodegenerative disorders. He has also edited 10 books and authored 25 book chapters. He has been granted three international patents and two Indian patents. Dr. Mishra is the recipient of the “Distinguished Professor Award” 2019 from DST-NSTMIS, SPAICS, Indore, and M.P. in September 2019. Dr. Mishra has also received the “Outstanding Scientist Award '' 2020, 6th International Scientist Awards on Engineering, Science, and Medicine, 20–21 June 2020, Chennai, India. Dr. Mishra has received the “Distinguished Professor Award '' 2021 from the Indian Pharmaceutical Association, MP State Branch, Indore. Dr. Mishra has received the “Best Academician Award” in the Indian Pharmacy Graduate Association, M.P. State International Conference held on May 6, 2023, at DAVV Auditorium, Indore, India.
Dr. Sumel Ashique has been working as an Assistant Professor at the Department of Pharmaceutical Sciences, Bengal College of Pharmaceutical Sciences & Research, Durgapur 713212, West Bengal, India. He has 3.5 years of teaching experience and has published more than 50 research studies and review articles in internationally and nationally accredited, reputed journals. He has been working in targeted drug delivery, nanotechnology, and gut microbiome. He has also been granted 5 patents from IP, and Australia and has authored more than 20 book chapters. He has edited 5 books under CRC Press, Springer, Wiley, and Taylor-Francis Publisher.
Dr. Arshad Farid is a distinguished academic and researcher with a prolific career spanning over 15 years in teaching and research. He is currently serving as an Assistant Professor in the Gomal Center of Biochemistry and Biotechnology at Gomal University, Pakistan. He completed his Ph.D. in Biotechnology from the Centre of Biotechnology and Microbiology (COBAM), University of Peshawar, Pakistan. His remarkable achievements have garnered him international recognition, as evidenced by his selection for the British Council-Charles Wallace Fellowship program for the academic year 2022-2023. In 2007, he was also awarded a prestigious scholarship to the University of Glasgow, UK, funded by the Higher Education Commission (HEC) of Pakistan. He has authored or co-authored more than 70 research papers and has been granted nine patents.
Dr. Ashish Garg obtained a B. Pharm. in 2011 and a M. Pharm. in 2013 from Guru Ramdas Khalsa Institute of Science and Technology, Pharmacy, Jabalpur, M.P., India. He has pursued his Ph.D. from SRK University, M.P. He has over 10 years of experience in both teaching and research. He has authored more than 100 research and review articles published in national and international journals of high repute. Additionally, he has edited ten books and been awarded three patents and one design patent. He is presently working as an Associate Professor in the Department of Pharmaceutics at Guru Ramdas Khalsa Institute of Science and Technology, Jabalpur, Madhya Pradesh, India.
