1st Edition
p53 in Breast Cancer Molecular Mechanisms, Clinical Implications, and Therapeutic Targets
This book comprehensively reviews the role of p53 in breast cancer development, progression, and treatment. It explores the multifaceted functions of p53, from its fundamental connection to breast cancer and pathway mechanisms to its influence on cancer metabolism and the impact of mutational alterations. The initial chapters discuss the complex landscape of p53's involvement in cancer metabolism, the ramifications of its mutations, and its crucial role as a tumor suppressor. The subsequent chapters review the regulatory functions of p53 in cell death, DNA repair, genomic stability, and cell cycle dynamics, highlighting its interactions with transcription factors, DNA repair enzymes, and family members p63 and p73. It further reviews the regulation of mutant p53 via post-translational modifications and delves into the approaches to combat mutated p53, highlighting targeted therapies and efforts to overcome chemoresistance. The chapters also address the role of p53 biomarkers in diagnosis and prognosis, the optimization of treatment responses, and the impact of nutrition on p53 activity. This book serves as an important source for researchers of oncology and molecular biology.
Key Features:
1) Provides a thorough examination of the p53 gene and its crucial involvement in breast cancer.
2) Explores the critical implications of mutational alterations in p53 on the development and progression of breast cancer.
3) Examines the role of p53 in managing apoptosis and contributing to DNA repair and genomic stability.
4) Discusses the complex interactions of p53 with transcription factors, DNA repair enzymes, p63 and p73.
5) Highlights the role of p53 as a biomarker in diagnosing and predicting breast cancer prognosis.
Chapter 1: Role of p53 in cancer metabolism
Authors: Inmbisat Altaf, Nusrat Jan, Shazia Sofi, Manzoor Ahmad Mir
Chapter 2: Exploring the Intricacies of p53 and its Connection to Breast Cancer
Authors: Sadaf Qadir, Nusrat Jan, Saima Gul, Manzoor Ahmad Mir
Chapter 3: P53 Pathways in the Progression of Breast Cancer
Authors: Ibtisam Mumtaz, Arfa Ji, Subzar Ah Ganaie, Dr. Faizan Shakeel, Adil Jameel Var, Manzoor Ahmad Mir
Chapter 4: Mutational Alterations in p53: Their Impact on the Development of Breast Cancer
Authors: Burhan Ul Haq, Asma Jan, Manzoor Ahmad Mir
Chapter 5: P53 and Cell Death Regulation: Managing Apoptosis in Breast Cancer
Authors: Arfa ji, Ibtisam Mumtaz, Nusrat Jan, Shahnaz Anjum, Aaqib Rashid, Asfer Hamid, Ehtisham-ul Haq, Manzoor Ahmad Mir
Chapter 6: The Contribution of p53 to DNA Repair and Genomic Stability in Breast Cancer
Authors: Iqra Jan, Asma Jan, Alia Jabar, Manzoor Ahmad Mir
Chapter 7: Interaction of mutant p53 with transcription factors and DNA repair enzymes
Authors: Adeeba Farooq, Nusrat Jan, Manzoor Ahmad Mir
Chapter 8: P53 Control of Cell Cycle Dynamics in Breast Cancer: Maintaining a Balance Between Proliferation and Arrest
Authors: Mehvish feroz, Asma Jan, Janifar Yasin, Manzoor Ahmad Mir
Chapter 9: The complex interplay between mutant p53, p63, and p73, and their effect on cellular processes.
Authors: Saima Gul, Nusrat Jan, Sadaf Qadir, Manzoor Ahmad Mir
Chapter10: Role of post-translational modifications in regulation of mutant P53
Authors: Gowhar Masoodi, Nusrat Jan, Asma Jan, Manzoor Ahmad Mir
Chapter11: Genetic alterations affecting p53 and Emerging Perspectives on Epigenetic Control of p53 in Breast Cancer
Authors: Alia Jabar, Nusrat Jan, Iqra Jan, Manzoor Ahmad Mir
Chapter12: Targeted Therapies against mutated p53 in Breast Cancer
Authors: Samridhi Kaul, Kirti Hooda, Mary Chatterjee, Asma Jan, Manzoor Ahmad Mir
Chapter13: The mevalonate pathway's involvement in cancer progression in the context of mutant p53
Authors: Janifar Yasin, Nusrat Jan, Mehvish feroz, Manzoor Ahmad Mir
Chapter 14: Interactions and Implications of p53 in Hormonal Signaling Pathways in Breast Cancer
Authors: Asma Jan, Nusrat Jan, Manzoor Ahmad Mir
Chapter 15: p53 as a diagnostic biomarker in Breast Cancer
Authors: Asma Jan, Nusrat Jan, Manzoor Ahmad Mir
Chapter 16: The Impact of Nutrition on p53 Activity: Implications for Preventing and Treating Breast Cancer
Authors: Tabish Javeed, Nusrat Jan, Manzoor Ahmad Mir
Chapter 17: The interplay between p53 and the tumor microenvironment in progressing breast cancer.
Authors: Shristi Handa, Mary Chatterjee, Nusrat Jan, Manzoor Ahmad Mir
Chapter 18: Current State and Future Avenues of p53 Gene Therapy in Breast Cancer
Authors: Jahnvi Arora, Mary Chatterjee, Nusrat Jan, Manzoor Ahmad Mir
Chapter 19: Insights from Genetic Studies: The Role of p53 in Hereditary Breast Cancer Syndrome
Authors: Akhil Jamwal, Mary Chatterjee, Kirti Hooda, Nusrat Jan, Manzoor Ahmad Mir
Chapter20: Bridging bench to bedside in breast cancer therapy: translational insights into p53 Research
Authors: Kirti Hooda, Mary Chatterjee, Nusrat Jan, Manzoor Ahmad Mir
Biography
Dr. Manzoor Ahmad Mir is presently working as a scientist and head of department at the Department of Bioresources, University of Kashmir. He holds master’s degree in Zoology with Gold Medal from HNBG Central University and got his Ph.D. from Jawaharlal Nehru University New Delhi and CSIR-Institute of Microbial Technology, Chandigarh, in the field of Immunopathology. His research interest is cancer biology with specialization in drug repurposing and combination therapy of breast cancer and to elucidate the molecular mechanism behind it, besides use of natural agents in treating cancer. He is also working on expression pattern and prognostic significance of chemokines/cytokines of CDKs in breast cancer, as well as the virtual screening of drugs for cancer treatment and their mechanistic elucidation. He has published more than 50 high-impact research papers and book chapters, in recognition of which he has received several awards. Dr. Manzoor has authored more than 16 books with international publishers. He is on the editorial board and reviewer of some prestigious journals and has been an invited speaker at various scientific meetings/conferences within India and abroad. He is member of many scientific organizations and societies, like American Association of Cancer Research, the Royal British Society, American Association of Clinical Oncology, International Immunology Association, etc. Dr Manzoor was awarded Teachers Associate Research Excellence Fellowship (TARE) by DST Govt of India and Summer Research Fellowship Programme (SRFP-2019) by Indian Academy of Sciences and National Science Academy. Dr Manzoor has developed Massive Open Online Course (MOOCs) in immunology, human genetics, and endocrinology for UG students sanctioned by UGC-Consortium for Educational Communication (CEC) SWAYAM Ministry of HRD Govt of India. He has research and teaching experience of 15 years in cancer biology, animal cell and tissue technology, molecular modelling and drug design, comparative immunology.
